by U.S. Environmental Protection Agency, Office of Research and Development, Environmental Monitoring Systems Laboratory, Available to the public through the National Technical Information Service in Las Vegas, Springfield, Va .
Written in English
|Statement||by Yogendra M. Patel and John A. Santolucito.|
|Series||Research reporting series. 3. Ecological research -- EPA-600/3-80-031., Research reporting series -- EPA-600/3-80-031.|
|Contributions||Santolucito, John A., Environmental Monitoring Systems Laboratory (Las Vegas, Nev.), Environmental Monitoring Systems Laboratory (Las Vegas, Nev.). Exposure Assessment Research Division.|
|The Physical Object|
|Pagination||vi, 8 p. ;|
When a paired feeding study design is to be employed, pairs of litter-mate weanling rats of the same sex and approximate size are selected and fed the control or the experimental diet. As for other control data, published data on reprotoxicology are rare and reports are limited to selected parameters. 51 In contrast, the complete set of data on different study types for the RccHan:WIST rat is available. 12 This rat stock has a high fecundity ( pups per litter) and little variation in reproductive success between the Cited by: The 30 male neonates were subcutaneously injected in the neck on P1, and five randomly selected rats were dissected on P2, P3, P4, P5, P6, or P7. The 30 weanling male rats were injected on P35, and five randomly selected rats were dissected on P36, P37, P38, P39, P40, or PCited by: 5. Male laboratory rats were bought locally from veterinary medicine college of animal house. The study was than on 2 groups of saprague dawelly white male rats, untreated control of 20 male rats and 40 male rats of young and adult as treated group. Control rats feed only on normal.
Weanling male rats were dosed by gavage from 21 to 50 days of age with vehicle (% methocel) or chemicals from the following EAC classes: an androgen (testosterone propionate [TP], or mg/kg/day), a broad-spectrum steroid biosynthesis inhibitor (ketoconazole [KETO], 24 mg/kg/day), a 5α-reductase inhibitor (finasteride [FIN], 20 or •The number and types of studies required depend on the therapeutic indication. • Drugs for life-threatening illnesses require fewer studies to reach the clinic. • In general, animal studies are conducted in two species, one rodent (e.g., rat, mouse) and one non-rodent (e.g., dog, nonhuman primate). Biologics may require only one species. In a recent in vivo study on weanling male rats, Riad et al.  reported that TCS, either alone or combined with butylparaben, reduced TSN, leutinizing hormone (LH), and follicle-stimulating. Robert W. Luebke's research works with 2, citations and 2, reads, including: Host Resistance Assays.
A review of studies published or in press. Cookies on CAB Direct. Dietary protein and pesticide toxicity in male weanling rats. Author(s): Boyd, E. M. Author Affiliation: Dept. Pharmacol., Queen's Univ., Kingston, Ont. Selected records only. Range eg 1 – , – This paper is a review summarizing the results of several years work by the author on the effect of alteration of dietary protein intake on the acute toxicity of pesticides. Weanling rats were fed on highly purified diets containing varying amounts of casein, or other proteins such as lactalbumin. Low, normal and high protein diets contained %, 26% and 81% casein. Purchase Male Reproductive Toxicology - 1st Edition. Print Book & E-Book. ISBN , According to EPA (), rats selected for these studies should be started on the test material shortly after weaning, ''ideally before the rats are 6 and, in any case, not more than 8 weeks old." For dogs, dosing should begin when they are 4 to 6 months of age and "not later than 9 months of age.".